LINEで予約[Official] At-Home Stem Cell and Stem Cell Exosome-Containing Culture Supernatant Nasal Therapy
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Since its opening in 2021, Setagaya Internal Medicine has been offering nasal therapy using stem cell exosome-containing culture supernatant. Please refer to the following for more information on stem cell exosomes and culture supernatants.
About Stem Cell Exosome Therapy
Setagaya Internal Medicine offers at-home stem cell exosome nasal therapy, which is used for the treatment of dementia prevention, brain disease improvement, post-stroke sequelae, post-COVID-19 syndrome, spinal cord injuries, and central nervous system diseases, particularly for conditions such as cervical spondylosis, cervical hernia, lumbar disc herniation, and cervical spinal canal stenosis. The therapy utilizes exosome-containing culture supernatant derived from stem cells.
In addition to disease treatment, this therapy is also widely used nationwide for health maintenance, skincare benefits, immune enhancement, AGA (androgenetic alopecia), ED (erectile dysfunction), menopause symptoms, hay fever countermeasures, and allergic rhinitis.
Stem Cell Exosome-Containing Culture Supernatant Developed by Anti-Aging Specialist
I have spent about 13 years working in university hospitals, general hospitals, home medical care, and as the director of a clinic in Tokyo, dedicating myself to the prevention and treatment of various internal diseases. In 2021, I established Setagaya Internal Medicine, a comprehensive diagnostic clinic, with a focus on regenerative medicine that can be administered at home from the outset.
I provide online consultations myself, ensuring personalized care and prescriptions for each patient, whether for self-care or for family members.
- Certified Diabetologist by the Japan Diabetes Society
- Certified Anti-Aging Specialist by the Japan Anti-Aging Medical Association
- Certified Internal Medicine Specialist by the Japanese Society of Internal Medicine
- Certified Occupational Physician by the Japan Medical Association
- Certified Food Education Planner by the Japan Taste Education Association
- Certified Food Coordinator by the Japan Food Coordinator Association
Regarding “Imitation Products” of Our Stem Cell Exosome Nasal Spray
Since the opening of Setagaya Internal Medicine in 2021, we have been offering nasal spray therapy using stem cell exosome culture supernatant. Recently, several stem cell exosome-containing nasal sprays have been advertised online, leading to an increase in inquiries about their differences compared to our products.
Our stem cell exosome-containing culture supernatants (max NFC, CLASS, EXOPure) used at Setagaya Internal Medicine Clinic are also utilized in IV therapies. They are manufactured in facilities approved by Japan’s Ministry of Health, Labor, and Welfare, using a natural cultivation method by experienced specialists without the use of antibiotics, preservatives, or externally added EGF. Impurities and ammonia generated during the culture process are completely removed.
The stem cells used as raw materials are not frozen but are harvested from donors and cultured within 24 hours to produce exosome-containing culture supernatant. (Typically, cells that have been frozen before culturing are partially damaged.)
Currently, the market is flooded with products of varying quality, some of which are reportedly diluted to several times or even hundreds of times the concentration of legitimate products.
The stem cell culture supernatants handled by our clinic are subject to strict safety standards and consistent quality control, ensuring uniformity and high quality throughout the production process. The high concentration of cytokines, which characterizes our super-concentrated stem cell supernatants, is also used in our exosome nasal sprays, ensuring safety and reliability for you and your family.
These nasal sprays are used in the treatment of patients undergoing rehabilitation in wards for brain diseases. Furthermore, a specialist physician with certified expertise conducts an online consultation with each patient before prescribing the most suitable type.
What is Nasal Therapy?
Nasal therapy involves inhaling stem cell culture supernatant and injecting it into the nasal cavity. This method allows patients to administer the treatment easily at home themselves after receiving counseling from a physician.
Limitations of Traditional Intravenous Infusions
With traditional intravenous infusions, the active ingredients in the culture supernatant cannot pass through the blood-brain barrier (BBB) of the brain’s capillaries.
Advantages of Nasal Administration
Therefore, in cases of brain diseases or functional decline due to aging, and for the treatment of central nervous system disorders such as spinal cord injuries, cervical spondylosis, and cervical spinal canal stenosis, administration through the nose is preferred over intravenous infusions.
As a result, this treatment method is reported to be highly effective in treating central nervous system disorders, including brain diseases, especially in the prevention and early-stage treatment of dementia. This efficacy is achieved because the active ingredients act directly on brain cells by passing through the olfactory bulb via the culture supernatant.
Effects on Hay Fever and Allergic Rhinitis
Additionally, because nasal sprays are administered directly to the nasal mucosa, exosome-containing nasal sprays are emerging as a new treatment option for symptoms such as runny nose, nasal congestion, sneezing, and itchy eyes caused by hay fever.
Hay fever is an allergic reaction triggered by pollen, resulting in symptoms like a runny nose, nasal congestion, sneezing, and itchy eyes. Traditional treatments for hay fever include antihistamines and steroid nasal sprays, but these often come with side effects and may not be effective for all patients.
Exosome-Containing Nasal Sprays as a New Treatment Option
Against this backdrop, nasal sprays utilizing exosomes are gaining attention as a new treatment option. Exosomes are tiny extracellular vesicles that play a crucial role in intercellular communication. They contain various beneficial molecules, including growth factors, neuroprotective factors, and angiogenic factors, which aid in cell regeneration and repair.
Recent research indicates that exosome nasal sprays can potentially improve hay fever symptoms fundamentally by delivering these molecules directly to the nasal mucosa. Specifically, the components within the exosomes act on the immune cells of the nasal mucosa to suppress excessive immune responses that trigger allergic reactions. This suppression helps reduce inflammation and alleviate symptoms. Furthermore, exosomes promote the repair and regeneration of the nasal mucosa, leading to long-term therapeutic effects.
Nasal Spray Treatment Effects for Alzheimer’s Disease Patients
According to Professor Emeritus Minoru Ueda from Nagoya University, the use of cultured supernatant shows remarkable improvement in patients with Alzheimer’s disease, stroke, atopic dermatitis, rheumatoid arthritis, and hay fever, among other intractable diseases. This cultured supernatant can be produced in liquid or powder form and is capable of mass production. Compared to the costs of stem cell transplantation, this treatment is only 1/100th the price and does not require expensive transplant surgery, being administrable via intravenous infusion, topical application, or nasal inhalation.
This innovative technology, which began large-scale collaborative clinical research with the University of Bergen, Norway, in 2019, possesses the ability to regenerate damaged cells in the body. Additionally, it has shown potential in treating interstitial pneumonia caused by the novel coronavirus and its sequelae, as well as amyotrophic lateral sclerosis (ALS), conditions that previously lacked specific treatments.
Stem Cell Exosome Nasal Administration as a Treatment Option for Post-COVID-19 Symptoms
Stem cell exosome nasal administration is gaining attention as a treatment option for post-COVID-19 symptoms.
Even four weeks after the onset of COVID-19, persistent symptoms, known as post-COVID-19 syndrome, have been reported, such as:
Brain Fog:
A cognitive impairment where it feels like there’s a fog in your mind, making it difficult to remember things.
Respiratory Issues:
Symptoms include cough, shortness of breath, chest pain, and discomfort.
Physical Function Disorders:
These include loss of smell and taste, fatigue, headaches, joint pain, and loss of appetite.
Mental and Cognitive Disorders:
Symptoms include post-traumatic stress disorder (PTSD), memory problems, anxiety, depression, insomnia, and loss of appetite.
The causes of these symptoms may include an overactive inflammatory response (cytokine storm), damage caused by the active virus itself, or an inadequate immune response, but they are not yet fully understood.
As a result, the treatment of post-COVID-19 symptoms can take a long time, and in some cases, symptoms may persist even a year after infection.
Even if the symptoms are mild, there is a possibility that various parts of the body have been damaged, leading to prolonged symptoms.
In Japan, specialized outpatient clinics for post-COVID-19 symptoms are still limited, and no established treatment method has been developed.
Since respiratory and neurological issues are common among post-COVID-19 symptoms, research has shown that the nasal administration of cultured supernatant can be effective.
Cultured supernatant has anti-inflammatory effects and acts as a scavenger of reactive oxygen species, potentially aiding in the repair of damaged cells and the activation of weakened cells.
The effectiveness of exosome nasal therapy for stroke, spinal cord injury,
and cervical spondylosis has gained increasing attention in recent years. Recent studies have reported that stem cell-derived exosomes can help reduce the aftereffects of stroke and spinal cord injuries and enhance rehabilitation outcomes.
The supernatant produced during stem cell culture contains cytokines, such as neuroprotective factors, growth factors, and angiogenesis factors, which activate brain stem cells and promote self-repair. Nasal administration has been shown to be more effective than intravenous delivery, as it allows the exosomes and cytokines to reach the brain quickly and at higher concentrations via the olfactory bulb and trigeminal nerve pathways.
This therapy has led to dramatic recoveries, with some spinal cord injury patients regaining the ability to walk independently within weeks after stem cell therapy. This approach is reported to be more than 10,000 times more effective than intravenous administration.
These advancements offer significant hope for treating stroke, central nervous system disorders, spinal cord injuries, cervical spondylosis, and cervical spinal canal stenosis. Exosomes, small vesicular structures secreted by cells, play a key role in cellular communication and are rich in components that promote the repair of damaged brain tissue. Research suggests that exosomes derived from stem cells may support the regeneration and functional recovery of brain regions affected by stroke.
Originally used to alleviate symptoms of dementia, stem cell supernatant nasal spray treatment is now also gaining attention as a therapy with anti-aging benefits, including improved skin health, hair growth, sexual function, and cognitive enhancement.
Expected Effects and Treatment Examples of Stem Cell Exosome Nasal Spray
Enhanced Mental Clarity
Nasal administration of dental pulp stem cell-derived conditioned media is expected to improve cognitive function, promoting clearer thinking and contributing to brain activation and nervous system health.
Dementia Improvement and Prevention
Continued nasal administration has shown promising trends in improving dementia symptoms, potentially delaying cognitive decline and enhancing quality of life.
Stroke Prevention and Recovery from Motor Dysfunction
Nasal administration of dental pulp stem cell-conditioned media has proven effective in improving motor function in stroke survivors, acting on the nervous system via the olfactory pathway to enhance recovery.
Central Nervous System Disease Treatment
Exosome nasal therapy shows positive effects in treating specific central nervous system disorders, including cervical spondylosis, cervical herniated discs, lumbar disc herniation, and cervical spinal canal stenosis. The treatment involves nasal administration of stem cell-derived exosomes, directly impacting the central nervous system, promoting neuroprotection, regeneration, and anti-inflammatory effects. Patients at our clinic report symptom relief and improved quality of life, supporting ongoing treatment.
Skin Benefits
Growth factors (EGF, FGF, etc.) and cytokines in stem cell-conditioned media are effective in treating skin aging issues (e.g., spots, wrinkles, uneven texture) and in repairing damaged skin, including keloids and inflammation.
Effects on Allergic Rhinitis and Hay Fever
Due to direct nasal mucosal delivery, exosome-containing nasal spray shows promise as a new treatment option for hay fever symptoms such as runny nose, nasal congestion, sneezing, and itchy eyes.
Impact on Diabetes
While direct effects on diabetes are still under investigation, stem cell therapy may indirectly contribute to treating chronic conditions like diabetes by enhancing tissue and organ regeneration capabilities.
Erectile Dysfunction (ED) Treatment
Stem cell-conditioned media is also used in treating ED, as it is believed to regenerate endothelial cells in the penile corpus cavernosum, thereby improving ED symptoms.
Hair Loss Treatment
Stem cell-conditioned media is utilized in treating male pattern baldness (AGA), with expected benefits in stimulating hair follicle cells, promoting hair growth, and encouraging hair regeneration.
Exosome Nasal Sprays at Setagaya Clinic
At Setagaya Clinic, we offer advanced stem cell exosome nasal therapy using the following formulations:
- EXOPure ASC: Cultured from adipose stem cells of Japanese women under 20.
- EXOPure P: Derived from stem cells of Japanese children’s dental pulp under 7 years old.
- THE Class: Sourced from Wharton’s jelly of 20-year-old Japanese umbilical cord.
- max NFC: A complex containing exosomes from four types of Japanese human stem cells (dental pulp, bone marrow, adipose, and umbilical cord blood).
All exosome solutions are produced in government-approved facilities using non-frozen stem cells, ensuring high concentration and quality.
maxNFC Exosome Nasal Spray
The maxNFC exosome nasal spray contains over 7.8 trillion exosomes, derived from four unique types of human stem cells: dental pulp, adipose tissue, umbilical cord, and bone marrow. This exclusive blend represents a groundbreaking innovation in regenerative medicine, protected by our proprietary technology.
Each batch is meticulously sourced from more than 4,000 donors to ensure consistency and effectiveness. These exosomes are produced without using frozen stem cells, maintaining their integrity and potency. The product undergoes rigorous testing for bacterial contamination, endotoxins, and cytokine levels to guarantee safety and efficacy.
EXO Pure ASC (Adipose-Derived) / P (Dental Pulp-Derived) Nasal Spray
This nasal spray utilizes high-concentration stem cell supernatant, rich in cytokines, commonly used in advanced regenerative medicine.
EXO Pure P (Dental Pulp-Derived) Nasal Spray
EXO Pure P contains exosomes derived from the dental pulp of children under 7 years old. These exosomes are particularly effective in the repair and regeneration of the nervous system, making them suitable for treating conditions such as ALS, stroke sequelae, cervical spondylosis, and lumbar disc herniation.
EXO Pure ASC (Adipose-Derived) Nasal Spray
Adipose-derived stem cells (ASC) possess self-replication capabilities and the ability to differentiate into various cells, including those involved in bone, cartilage, cardiac muscle, and angiogenesis. They also play a role in wound healing and immune modulation. Additionally, these cells act similarly to fibroblasts, producing collagen and hyaluronic acid, resulting in increased skin thickness and moisture.
High-Concentration Stem Cell Supernatant Nasal Spray
Developed by an experienced team with 20 years of expertise in human stem cell research, this nasal spray incorporates stem cell supernatant derived from adipose and dental pulp stem cells, as used in regenerative medicine.
Superiority in Cytokine Content
Our product was tested in top-tier laboratories, revealing that its cytokine content is over 200 times higher in TGF-β and 360 times higher in VEGF compared to leading products in the market, demonstrating its unmatched potency.
Pure, High-Concentration Stem Cell Supernatant
Our supernatant is produced without antibiotics, preservatives, or the addition of externally prepared growth factors like EGF. It is crafted using a unique cultivation technique by skilled specialists.
Consistent Cytokine Levels
Each production unit undergoes precise measurement to ensure consistent cytokine levels, adhering to our strict standards. The technology we use allows for balanced distribution of cytokines and exosomes, ensuring a stable and potent product. The non-invasive nasal delivery method makes it a convenient option for home care.
EXO Pure: Unmatched Cytokine and Exosome Levels
Tests have confirmed that EXO Pure contains over 200 times more TGF-β and 360 times more VEGF than other products, with over 20 billion exosomes.
Product Safety and Testing
Our products, including the supernatant from human dental pulp and adipose tissue stem cells, are thoroughly tested to ensure they are free from contaminants like HIV-1, HIV-2, HBV, HCV, HTLV-1, HTLV-2, and Mycoplasma. Pre-shipment tests include sterility, endotoxin, Mycoplasma, and pH testing, meeting the same standards as those used in regenerative medicine.
Here are testimonials from actual patients:
- “The quality of my sleep has greatly improved.”
- “Using it between IV treatments made the effects more noticeable.”
- “I find myself less foggy and more alert.” ✓ “My mother with dementia has shown signs of improvement.”
- “I noticed I get tired less easily.”
- “My morning wake-up is much better, and my daytime energy has increased, improving my work performance.”
- “I had been using various medications for lumbar disc herniation, but since using the nasal spray, I no longer need them on weekends.”
- “Within weeks of use, my skin regained its firmness and radiance.”
- “I suffered from severe pain and numbness due to cervical spinal stenosis, but after just one use of the nasal spray, the pain disappeared as if it was never there.”
These are just some of the positive feedback we’ve received.
We have received various positive feedback from patients.
Given that this treatment involves nasal administration rather than injections or IVs, it is a non-invasive option that can be easily incorporated into your home care routine.
Shipping is available within Japan (and can be carried on flights as hand luggage). For more details, please contact us via the LINE link provided below.
Price
１vial（2cc/１vial）
- １vial
- 330,000yen
- ２vial
- 638,000yen
- ４vial
- 1,100,000yen
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